Welcome to HeLab of IRCBC, CAS

Impaired adrenergic regulation of Kv channels underlies LC hyperactivity and early-onset sleep disruption in AD-like amyloidogenic mice

( BioRxiv , 2025, revision in Alzheimer's & Dement) Article Link

Y-C Zhang, X-T Zhang, P-Y Chen, Z-Y Zhou, M-Q Huang, K-W He*

Behavior- and Cell Type-Specific Cortico-Striatal Decoupling in a Parkinson’s Disease-Like Mouse Model

( Advanced Science , 2025, Accepted) Article Link

X-R Yao, Y Liu, W-T Zheng, M-Q Huang, K-W He*

Aspirin inhibits proteasomal degradation and promotes α-synuclein aggregate clearance through K63 ubiquitination

( Nature Communication , 2025 Feb 7;16(1):1438. doi: 10.1038/s41467-025-56737-6） Article Link

Gao J#, Liu Y#, Si C, Guo R, Hou S, Liu X, Long H, Liu D, Xu D, Zhang Z-R, Liu C, Shan B, Turck CW, He K, Zhang Y

dAux orchestrates the phosphorylation-dependent assembly of the lysosomal V-ATPase in glia and contributes to α-synuclein degradation

( Autophagy .2025 Jan 29;21(5):1039–1058. doi: 10.1080/15548627.2024.2442858） Article Link

Shiping Zhang, Linfang Wang, Shuanglong Yi, Yu-ting Tsai, Honglei Wang, Shuhua Li, Ruiqi Wang, Yang Liu, Wei Yan, Chang Liu, Kai-Wen He, Margaret S. Ho*

Pericyte signaling via soluble guanylate cyclase shapes the vascular niche and microenvironment of tumors

( EMBO J . 2024 Apr;43(8):1519-1544. doi: 10.1038/s44318-024-00078-5) Article Link

Zhu J, Yang W, Ma J, He H, Liu Z, Zhu X, He X, He J, Chen Z, Jin X, Wang X, He K, Wei W, Hu J*

RIPK1 activation in Mecp2-deficient microglia promotes inflammation and glutamate release in RTT

( Proc Natl Acad Sci U S A . 2024 Feb 6;121(6):e2320383121. doi: 10.1073/pnas.2320383121) Article Link

Cao Z, Min X, Xie X, Huang M, Liu Y, Sun W, Xu G, He M, He K, Li Y, Yuan J

Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging

( Nat Struct Mol Biol . 2024 Feb;31(2):232-245. doi: 10.1038/s41594-023-01163-9) Article Link

Guo R, Liu J, Min X, Zeng W, Shan B, Zhang M, He Z, Zhang Y, He K, Yuan J, Xu D

miR-34a regulates silent synapse and synaptic plasticity in mature hippocampus

( Progress in Neurobiology . 2023 Jan 12;102404. doi: 10.1016/j.pneurobio.2023.102404) Article Link

X Min, J-Y Wang, F-J Zong, J Zhao, N Liu, K-W He*

Circadian time- and sleep-dependent modulation of cortical parvalbumin-positive inhibitory neurons

( EMBO J . 2022 Dec 7;e111304. doi: 10.15252/embj.2022111304) Article Link

F-J Zong, X Min, Y Zhang, Y-K Li, X-T Zhang, Y Liu, K-W He*

Brain region-specific synaptic function of FUS underlies the FTLD-linked behavioral disinhibition.

( Brain . 2022 Nov 8;awac411. doi: 10.1093/brain/awac411) Article Link

J-Y Wang, G-M Ma, X-Q Tang, Q-L Shi, M-C Yu,M-M Lou, K-W He, W-W Wang

A Multisubcellular Compartment Model of AMPA Receptor Trafficking for Neuromodulation of Hebbian Synaptic Plasticity

( Front Synaptic Neurosci . 2021;13:703621. doi: 10.3389/fnsyn.2021.703621) Article Link

Mihalas S, Ardiles A, He K, Palacios A, Kirkwood A

Wild-type α-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding.

( PNAS . 2021 May 18;118(20):e2012435118. doi: 10.1073/pnas.2012435118) Article Link

Long H¶, Zheng W¶, Liu Y, Sun Y, Zhao K, Liu Z, Xia W, Lv S, Liu Z, Li D, He K-W, Liu C

Ion mobility-based sterolomics reveals spatially and temporally distinctive sterol lipids in the mouse brain

( Nat Commun . 2021 Jul 15;12(1):4343. doi: 10.1038/s41467-021-24672-x) Article Link

Li T, Yin Y, Zhou Z, Qiu J, Liu W, Zhang X, He K, Cai Y, Zhu ZJ

Daily Oscillation of the Excitation-Inhibition Balance in Visual Cortical Circuits.

( Neuron . 2020 Feb 19;105(4):621-629.e4. doi: 10.1016/j.neuron.2019.11.011) Article Link

M Bridi.¶, F-J Zong.¶, X Min N Luo, T Tran, J Qiu, D Severin, X-T Zhang, G Wang, Z-J Zhu, K-W He, A Kirkwood

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